Synthesis of Narbonolide, muamvitin and (s) – (5)-[(s)-6-hyrdoxyoctyl]: Stereoselective synthesis
The present invention provides methods and reagents relating to the PKS gene cluster for the polyketide antibiotics known as narbomycin and picromycin. Narbomycin is produced in Streptomyces narbonensis and both narbomycin and picromycin are produced in S. venezuelae. We have completed the formal synthesis of Narbonolide by using Yamaguchi esterification protocol. Muamvatin represents the first example of a naturally occurring 2,4,6-trioxaadamantane ring skeleton. Pulmonate molluscs of the genus Siphonaria are known for their characteristic production of polypropionate metabolites containing either a hydroxylated pyrone or ketal functionality. The formal synthesis of Muamvatin has been achieved in a stereocontrolled manner by silyltriflate mediated opening of epoxy alcohol and desymmetrization of the meso-bicyclic dihydrofuran using an asymmetric hydroboration. This synthetic sequence provides an easy access to the construction of the key fragments of Muamvatin.
yazar | B. Jagan Mohan Reddy |
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Boyutlar ve boyutlar | 15 x 0,9 x 22 cm |
Tarafından yayınlandı | 26 Mayıs 2020 |
ROBERT H BORK 29 Ekim 2011 18,9 x 0,5 x 24,6 cm 1 Ocak 2017 WADE H MCCREE Mdpi AG 30 Ekim 2011 3 Ocak 2017 28 Ekim 2011 15 x 0,5 x 22 cm Additional Contributors 18,9 x 0,3 x 24,6 cm 18,9 x 0,2 x 24,6 cm Kolektif ERWIN N GRISWOLD 18,9 x 0,6 x 24,6 cm 28 Şubat 2018 18,9 x 0,4 x 24,6 cm
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Sürüm ayrıntıları
yazar | B. Jagan Mohan Reddy K. V. B. Ranjitha A. Kavitha |
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isbn 10 | 6202564326 |
isbn 13 | 978-6202564328 |
Yayımcı | LAP LAMBERT Academic Publishing |
Dilim | İngilizce |
Boyutlar ve boyutlar | 15 x 0,9 x 22 cm |
Tarafından yayınlandı Synthesis of Narbonolide, muamvitin and (s) – (5)-[(s)-6-hyrdoxyoctyl]: Stereoselective synthesis | 26 Mayıs 2020 |
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