Total Synthesis of Indole Alkaloids: Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations (Springer Theses) okumak kayıt olmadan

Total Synthesis of Indole Alkaloids: Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations (Springer Theses)

Ders Kitapları

This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide.  The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine.  These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.

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15 x 0,5 x 22 cm WADE H MCCREE 28 Ekim 2011 18,9 x 0,5 x 24,6 cm 18,9 x 0,6 x 24,6 cm 18,9 x 0,4 x 24,6 cm Kolektif 1 Ocak 2017 Additional Contributors ROBERT H BORK ERWIN N GRISWOLD 28 Şubat 2018 3 Ocak 2017 30 Ekim 2011 Mdpi AG 18,9 x 0,2 x 24,6 cm 18,9 x 0,3 x 24,6 cm 19 Eylül 2020

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