Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand
The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).
yazar | M. A. Affan |
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Tarafından yayınlandı | 15 Şubat 2012 |
15 x 0,6 x 22 cm 28 Şubat 2018 21,6 x 0,6 x 27,9 cm 15 x 0,4 x 22 cm 15 x 0,7 x 22 cm 1 Ocak 2016 1 Ocak 2017 BrownTrout Publisher Flower Love Press 15 x 0,5 x 22 cm Dazzle Book Press 30 Eylül 2020 Collectif 1 Haziran 2018 15 x 0,3 x 22 cm 1 Ocak 2018 Kolektif U.S. Department of the Interior
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Sürüm ayrıntıları
yazar | M. A. Affan M. A. Salam |
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isbn 10 | 9783848405695 |
isbn 13 | 978-3848405695 |
Yayımcı | LAP LAMBERT Academic Publishing |
DE OLDUĞU GİBİ | 3848405695 |
Tarafından yayınlandı Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand | 15 Şubat 2012 |
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