Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives: Aryl Propionic Acid Derivatives okumak kayıt olmadan

Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives: Aryl Propionic Acid Derivatives

Ders Kitapları

The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

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28 Ekim 2011 Kolektif 29 Ekim 2011 30 Ekim 2011 WADE H MCCREE 18,9 x 0,6 x 24,6 cm 18,9 x 0,5 x 24,6 cm ROBERT H BORK 1 Ocak 2017 ERWIN N GRISWOLD Mdpi AG 18,9 x 0,4 x 24,6 cm 15 x 0,5 x 22 cm Additional Contributors 28 Şubat 2018 18,9 x 0,3 x 24,6 cm 18,9 x 0,2 x 24,6 cm 3 Ocak 2017

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