Protein Folding and Metal Ions: Mechanisms, Biology and Disease
The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding and Metal Ions: Mechanisms, Biology and Disease presents the contributions of a cadre of international experts who offer a comprehensive exploration of this timely subject at the forefront of current research. Divided into four sections, this volume: Provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of co-factors Reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein Illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases, from cancer to protein deposition disorders such as Parkinsons disease Addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides dissecting the relative energetic contribution of metals sites to protein folding and stability Together, the 13 chapters in this text cogently describe the state of the science today, illuminate current challenges, propose future possibilities, and encourage further study in this area that offers much promise especially with regard to novel approaches to the treatment of some of the most challenging and tragic diseases.
| yazar | CRC Press |
|---|---|
| Tarafından yayınlandı | 30 Eylül 2020 |
18,9 x 0,3 x 24,6 cm 18,9 x 0,5 x 24,6 cm 15 x 0,5 x 22 cm 28 Ekim 2011 18,9 x 0,6 x 24,6 cm Mdpi AG Kolektif 30 Ekim 2011 ERWIN N GRISWOLD 1 Ocak 2017 18,9 x 0,4 x 24,6 cm Additional Contributors 3 Ocak 2017 28 Şubat 2018 WADE H MCCREE 30 Eylül 2020 ROBERT H BORK 18,9 x 0,2 x 24,6 cm
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Sürüm ayrıntıları
| yazar | CRC Press |
|---|---|
| isbn 10 | 0367655888 |
| isbn 13 | 978-0367655884 |
| Yayımcı | CRC Press |
| Tarafından yayınlandı Protein Folding and Metal Ions: Mechanisms, Biology and Disease | 30 Eylül 2020 |
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