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Pediatric Anthrax: Implications for Bioterrorism Preparedness

In response to the 2001 U.S. anthrax attack, there has been a proliferation of guidelines for the diagnosis and treatment of patients with anthrax. However, most of these have not specified screening and management protocols for specific populations, such as children. Efforts to prepare for and respond to future attacks of anthrax bioterrorism will be aided by detailed information about the clinical presentation and treatment responses of both adult and pediatric populations exposed to anthrax. A systematic review of case reports of pediatric anthrax were performed to describe the clinical course, treatment responses, and predictors of disease progression and mortality for children with anthrax infection. In addition to cases of inhalational, gastrointestinal, and cutaneous anthrax, we included in our analysis case reports of primary anthrax meningoencephalitis (without an identifiable inhalational, gastrointestinal, or cutaneous source). The data from English-language case reports of children with anthrax addressed three key research questions: 1. What is the evidence for an age-dependent clinical course associated with anthrax? 2. How effective are antibiotic prophylaxis and treatment for anthrax in children compared to adults? Similarly, how effective are other medical treatments in children compared to adults (e.g. ventilator/respiratory support)? 3. Based on the review of evidence for Questions 1 and 2, what are the implications for children versus adults in terms of preparedness and response planning for anthrax exposure (i.e., healthcare provider education on diagnosis and management, considerations for hospitals, vaccination strategies)?

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WADE H MCCREE Additional Contributors 18,9 x 0,4 x 24,6 cm 18,9 x 0,6 x 24,6 cm ROBERT H BORK 3 Ocak 2017 28 Ekim 2011 29 Ekim 2011 Kolektif 1 Ocak 2017 18,9 x 0,5 x 24,6 cm 18,9 x 0,3 x 24,6 cm 18,9 x 0,2 x 24,6 cm 21,6 x 0,5 x 27,9 cm Mdpi AG 30 Ekim 2011 ERWIN N GRISWOLD 28 Şubat 2018
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Sürüm ayrıntıları
yazar U.S. Department of Health and Human Services Agency for Healthcare Research and Quality
isbn 10 149970738X
isbn 13 978-1499707380
Yayımcı CreateSpace Independent Publishing Platform
Dilim İngilizce
Boyutlar ve boyutlar 21,6 x 0,5 x 27,9 cm
Tarafından yayınlandı Pediatric Anthrax: Implications for Bioterrorism Preparedness 28 Mayıs 2014
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