Izuchenie gena GSTP1 u bol'nykh rakom molochnoy zhelezy v KBR: monografiya
Onkogenez yavlyaetsya rezul'tatom deystviya mnogikh genov tak nazyvaemoy gennoy seti, a genam biotransformatsii ksenobiotikov otvoditsya rol' modifikatorov funktsiy glavnykh genov. Sboi v sisteme detoksikatsii ksenobiotikov okazyvayut sushchestvennoe vliyanie na razvitie RMZh. Byl proveden analiz genov, kontroliruyushchikh detoksikatsiyu ksenobiotikov u bol'nykh RMZh, prozhivayushchikh na territorii KBR. Vyyavleny chastoty vstrechaemosti polimorfizma Ile105Val gena GSTP1 u bol'nykh RMZh i v kontrol'noy gruppe. Sravnitel'nyy analiz chastot alleley issleduemogo polimorfnogo varianta mezhdu bol'nymi rakom molochnoy zhelezy i gruppoy kontrolya pokazal, chto chastota allelya Ile dostigaet 92.5% u bol'nykh RMZh i 98 % u zdorovykh lits. Chastota alleli Val v issledovannoy gruppe bol'nykh ravna 0,075, togda kak v kontrol'noy gruppe sostavila 0,012. Genotip IleIle vyyavlen s chastotoy 97.5% (39/40 chel) i 85% (34/40 chel.) u zdorovykh lits i bol'nykh RMZh, sootvetstvenno. Geterozigotnyy genotip identifitsirovan s chastotoy 2.5% (1/40 chel) u kontrol'noy gruppy i 15% (6/40 chel.) u bol'nykh RMZh. Gomozigoty po allelyu Val ne byli zaregistrirovany ni v odnoy iz vyborok.
15 x 0,5 x 22 cm 1 Ocak 2018 1 Ocak 2017 Flower Love Press 1 Haziran 2018 21,6 x 0,6 x 27,9 cm U.S. Department of the Interior 15 x 0,6 x 22 cm 1 Ocak 2016 30 Eylül 2020 Kolektif Dazzle Book Press 15 x 0,7 x 22 cm Collectif 15 x 0,3 x 22 cm 15 x 0,4 x 22 cm 28 Şubat 2018 BrownTrout Publisher
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Sürüm ayrıntıları
| yazar Izuchenie gena GSTP1 u bol'nykh rakom molochnoy zhelezy v KBR: monografiya | Diana Feliksovna Kumykova Zalina Ikhsanovna Bogotova Madina Mukhamatovna Bittueva |
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